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Specific growth and psychomotor development charts have been established.Two genes, Semaphorin F (), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in Cd CS patients.Most individuals who have 5p- Syndrome have difficulty with language.

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Cri-du-chat also carries many disabilities and abnormalities.Use the relatively good receptive skills to encourage language and communicative development rather than relying on traditional verbal methods.Behavior modification programs may be successful in managing hyperactivity, short attention span, low threshold for frustration, and self-stimulatory behaviors (eg, head-banging, hand-waving).Years ago, it was common to place children with 5p- Syndrome in institutions with other severely developmentally delayed individuals.

During the early 1980s, research revealed that those raised in family settings with the benefit of early intervention programs made remarkable progress, far exceeding the expectations of doctors who first described the syndrome.A small number of children are born with serious organ defects and other life threatening medical conditions, although most individuals with 5p- can anticipate a normal life expectancy.

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